How Much Do We Know About Blood Sugar Supplements?

Blood Sugar Supplements

June 1st, 2020   |   Updated on June 25th, 2020

 How Much Do We Know About Dietary Supplements For Diabetes?

Many studies have investigated dietary supplements for preventing or treating type 2 diabetes or its complications (the focus of this fact sheet).

What Do We Know About The Effectiveness Of Dietary Supplements For Diabetes?

For a few dietary supplements, there is weak evidence of a possible benefit. For example, chromium might help with blood sugar control, and alpha-lipoic acid might be helpful for diabetic neuropathy (nerve problems). For most supplements, however, there isn’t evidence to support a beneficial effect on diabetes or its complications.

What Do We Know About The Safety Of Dietary Supplements For Diabetes?

  • Some dietary supplements may have side effects, and some of these side effects, such as kidney damage, can be serious.
  • The U.S. Food and Drug Administration (FDA) is warning consumers about products for diabetes that seem too good to be true, such as those that claim to be a “natural diabetes cure” or to “replace your diabetes medicine.” These products are marketed illegally. Some are harmful in themselves, and all are harmful if people use them in place of effective diabetes treatment.
  • It’s very important not to replace medical treatment for diabetes with an unproven health product or practice.

About Diabetes

  • Diabetes is a disease that occurs when your blood glucose, also called blood sugar, is too high. Over time, having too much glucose in your blood can cause health problems.
  • About 9.4 percent of the people in the United States have diabetes, but about one in four people who have diabetes don’t know it.
  • Although diabetes has no cure, people with diabetes can take steps to manage their condition and stay healthy. Taking insulin or other diabetes medicines is often part of treating diabetes, along with healthy food choices and physical activity.
  • The most common type of diabetes is type 2 diabetes, in which your body does not make or use insulin well. This type of diabetes occurs most often in middle-aged and older people, but it can develop at any age, even in childhood.
  • You are more likely to develop type 2 diabetes if you are 45 years old or older, have a family history of diabetes, or are overweight. Physical inactivity, race, certain health problems such as high blood pressure, having prediabetes, or having had gestational diabetes while pregnant also affect your likelihood of developing type 2 diabetes.

What The Science Says About The Effectiveness And Safety Of Dietary Supplements For Diabetes

1. Alpha-Lipoic Acid

Alpha-lipoic acid is being studied for its effect on complications of diabetes, including diabetic macular edema (an eye condition that can cause vision loss) and diabetic neuropathy (nerve damage caused by diabetes).
In a 2011 study of 235 people with type 2 diabetes, 2 years of supplementation with alpha-lipoic acid did not help to prevent macular edema.

A 2016 assessment of treatments for symptoms of diabetic neuropathy that included 2 studies of oral alpha-lipoic acid, with a total of 205 participants, indicated that alpha-lipoic acid may be helpful.


  • High doses of alpha-lipoic acid supplements can cause stomach problems.

2. Chromium

Found in many foods, chromium is an essential trace mineral. If you have too little chromium in your diet, your body can’t use glucose efficiently.

Taking chromium supplements, along with conventional care, slightly improved blood sugar control in people with diabetes (primarily type 2) who had poor blood sugar control, a 2014 review concluded. The review included 25 studies with about 1,600 participants.


Chromium supplements may cause stomach pain and bloating, and there have been a few reports of kidney damage, muscular problems, and skin reactions following large doses. The effects of taking chromium long-term haven’t been well investigated.

3. Herbal Supplements

We don’t have reliable evidence that any herbal supplements can help to control diabetes or its complications.
There are no clear benefits of cinnamon for people with diabetes.

Other herbal supplements studied for diabetes include bitter melon, various Chinese herbal medicines, fenugreek, ginseng, milk thistle, and sweet potato. Studies haven’t proven that any of these are effective, and some may have side effects.


We have little conclusive information on the safety of herbal supplements for people with diabetes.

Cassia cinnamon, the most common type of cinnamon sold in the United States and Canada, contains varying amounts of a chemical called coumarin, which might cause or worsen liver disease. In most cases, cassia cinnamon doesn’t have enough coumarin to make you sick.

However, for some people, such as those with liver disease, taking a large amount of cassia cinnamon might worsen their condition.

Using herbs such as St. John’s wort, prickly pear cactus, aloe, or ginseng with conventional diabetes drugs can cause unwanted side effects.

4. Magnesium

Found in many foods, including in high amounts in bran cereal, certain seeds and nuts, and spinach, magnesium is essential to the body’s ability to process glucose.

Magnesium deficiency may increase the risk of developing diabetes. A number of studies have looked at whether taking magnesium supplements helps people who have diabetes or who are at risk of developing it. However, the studies are generally small and their results aren’t conclusive.


Large doses of magnesium in supplements can cause diarrhea and abdominal cramping. Very large doses—more than 5,000 mg per day—can be deadly.

5. Omega-3s

Taking omega-3 fatty acid supplements, such as fish oil, hasn’t been shown to help people who have diabetes control their blood sugar levels or reduce their risk of heart disease.

Fish and other seafood, especially cold-water fatty fish such as salmon and tuna, contain omega-3 fatty acids. Studies on the effects of eating fish have had conflicting results, according to two 2012 research reviews with hundreds of thousands of participants, and a 2017 review.

Some research from the United States and Europe found that people who ate more fish had a higher incidence of diabetes. Research from Asia and Australia found the opposite—eating more fish was associated with a lower risk of diabetes. There’s no strong evidence explaining these differences.


Omega-3 supplements don’t usually have side effects. When side effects do occur, they typically consist of minor symptoms, such as bad breath, indigestion, or diarrhea.

Omega-3 supplements may interact with drugs that affect blood clotting.

6. Selenium

An assessment of 4 studies involving more than 20,000 total participants found that selenium supplementation did not reduce the likelihood that people would develop type 2 diabetes.


Long-term intake of too much selenium can have harmful effects, including hair and nail loss, gastrointestinal symptoms, and nervous system abnormalities.

7. Vitamins

Studies generally show that taking vitamin C doesn’t improve blood sugar control or other conditions in people with diabetes. However, a 2017 research review of 22 studies with 937 participants found weak evidence that vitamin C helped with blood sugar in people with type 2 diabetes when they took it for longer than 30 days.

Having low levels of vitamin D is associated with an increased risk of developing a metabolic disorder, such as type 2 diabetes, metabolic syndrome, or insulin resistance, studies and research reviews from the past 5 years have found.

However, taking vitamin D doesn’t appear to help prevent diabetes or improve blood sugar levels for adults with normal levels, prediabetes, or type 2 diabetes, a 2014 research review of 35 studies with 43,407 participants showed.


Taking too much vitamin D can cause nausea, constipation, weakness, kidney damage, disorientation, and problems with your heart rhythm. You’re unlikely to get too much vitamin D from food or the sun.

Other Supplements

The evidence is still very preliminary on how supplements or foods rich in polyphenols—antioxidants found in tea, coffee, wine, fruits, grains, and vegetables—might affect diabetes

This article is republished from NIH. Read the original article here.